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Ketones – Water on the Fire of Chronic Disease

Let’s analogize the immune system to an army. Like an army, the immune system exists to protect us from foreign invaders. On the other hand, also like an army, a poorly directed immune system can wreak havoc on the body it’s supposed to protect.

And, just like an army, our immune system has its military generals. One of these generals is called “the NLRP3 inflammasome,” but we will just call him “General N.” Unfortunately, our modern diets and stressful lifestyles have made General N a little too trigger happy, leading him to erroneously and continuously direct the soldiers under his command (white blood cells) to go remain the offensive on our home turf. The result is what doctors and scientists refer to as “chronic inflammation,” a metabolic state known to play an important part in the development of almost all chronic diseases, such obesity, diabetes, heart disease, multiple sclerosis, osteoporosis, inflammatory bowel disease, and Alzheimer’s disease.

Research published in the prestigious journal Nature Medicine suggests that ketone bodies, biomolecules made by our liver during fasting or when someone is on a ketogenic diet, block General N’s orders and, thereby, protects you from the disease-causing toxic effects of chronic inflammation! What’s more, the researchers were able to show, in mice, that a ketone supplement, such as those that are now available to you on the public market, was able to override the General N’s command and decrease markers of inflammation.

Some technical details for those who are interested

The researchers showed that the ketone body β-Hydroxybutyrate prevented the NLRP3 inflammasome from assembling into a complete complex. Interestingly, the mechanism by which β-Hydroxybutyrate blocked NLRP3 neither involved β-Hydroxybutyrate being metabolized, nor did it involved β-Hydroxybutyrate binding to its most common signaling partners (HCAR2 and HDACs). Instead, β-Hydroxybutyrate appeared to inhibit the NLRP3 inflammasome by a new mechanism, by blocking the flow of potassium ions out of cells.


No medical advice

The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.



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